Duodenal sleeve bypass device (EndoBarrier Gastrointestinal Liner)

Imperial College Healthcare Research

london clinical research, uk healthcare research

Research area: Type 2 diabetes mellitus, obesity and gastroenterology
Location:St Mary’s Hospital and Hammersmith Hospital
Brief description: A new device called the EndoBarrier Gastrointestinal Liner helps patients with type 2 diabetes mellitus manage their blood sugar levels and lose weight without the need for surgery. This study will compare how effective the EndoBarrier device is compared to other standard medical care in the treatment of type 2 diabetes mellitus through a randomised controlled trial.

The EndoBarrier is a 60 cm long impermeable sleeve-like device that is inserted through the stomach. It creates a thin layer between food and the wall of the intestine. It may prevent food from coming into contact with the gut until further down the intestine and could alter the level of hunger and fullness that the person is experiencing.

Participants will either receive the EndoBarrier device for 12 months and subsequently a diet for a further 12 months after the implant, or they will receive a standard medical therapy and a diet for 24 months. All patients will receive specialist support from a dietitian and a doctor who specialises in the treatment of diabetes.

Participants will be required to attend 15 appointments over a two year period. Five of these visits will last approximately eight hours. All remaining visits will last no more than two hours. Patients will also be contacted over the phone in-between each visit to ensure they are healthy, happy and motivated.

Participant information: All participants need to be: Between 18 and 65 years old, have a BMI of 30 to 50 kg/m2 and taking oral T2DM medications.
How to take part: If you would like to take part in this study please contact Dr Aruchuna Mohanaruban by sending an email to endobarrier@imperial.nhs.uk or calling 0207 594 5946 or 078 7285 0052.