Primary Trial ID Number
The purpose of this study is to understand more about why young people who were born prematurely may have increased risk of high blood pressure and lower cardiovascular exercise capacity.
Young adults with a history of preterm birth are identified as having a unique risk profile for developing hypertension and having reduced exercise capacity. Globally, there are 15 million annual preterm births. In Europe, incidence is 6-15% of all births, with up to 6 million adults in the United Kingdom having a preterm birth history. Understanding the associations between early life exposures and this early cardiovascular risk is extremely important to be able to target primary prevention strategies. As yet there are no clear explanations for the reduced exercise capacity and elevated risk of hypertension reported in preterm born young adults. Magnetic resonance imaging studies of young adult born premature demonstrated altered heart shape, with increased left ventricular mass, reduced cavity sizes and reduced stroke volumes. The changes in cardiac size identified from these studies is similar to those seen in other disease groups and has been equated to greater than 50% increased risk of cardiovascular clinical events in these groups. These structural changes may account for the reduced exercise capacity observed in preterm born young adults This study aims to understand the physiological determinants of limited exercise capacity and associated cardiovascular risk profile of adult preterm born populations.
Observational Model: Case Control, Time Perspective: Prospective
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See Interventions above
Primary Outcome Measures
Cardiopulmonary Exercise Capacity; Single measure, baseline study recruitment
Secondary Outcome Measures
Cardiac Structure; Single measure, baseline recruitment; Cardiac Function; Single measure, baseline recruitment; Liver Structure; Single measure, baseline recruitment; Brain structure; Second study visit within 6 months of recruitment; Vascular function; Single measure, baseline recruitment; Dynamic cardiac function; Single measure, baseline recruitment
18 Years – 40 Years
Number of Participants
Participant Inclusion Criteria
– Participant is willing and able to give informed consent for participation in the
– Male or Female, aged 18 to 40 years.
– History of preterm birth, diagnosis of hypertension or full term birth normotensive
– Able (in the investigator’s opinion) and willing to comply with all study
– Participant is freely able to access John Radcliffe Hospital for study visits
– Aged <18 years >40 years
– Unwilling or unable to give informed consent for participation in the study.
– Pregnant or lactating during the course of the study.
– Planning to donate blood during the study duration.
– Any significant disease or disorder which, in the opinion of the investigator, might
influence the participant’s ability to participate in the study.
– Contraindication to Magnetic Resonance Imaging